He and She MD review

What I actually think of He and She MD

A broad compounded-plus-brand menu with seven real price points — $199/mo standard semaglutide down to $99/mo on the 12-month plan — though nearly every itemized figure is the annual-prepay rate, and tirzepatide's standard monthly cost isn't published. It runs about $99/month, and it's flat at every dose — toward the cheaper end of what I walked.

I look at He and She MD the way moms actually have to — not just the real monthly number, but nursing and pregnancy timing and the real monthly cost. That's the stuff a generic weight-loss review skips right over.

What He and She MD really costs

• Compounded semaglutide — Injectable, standard monthly: $199/mo
• Compounded semaglutide — Injectable, 12-month plan: $99/mo
• Oral semaglutide — Oral, 12-month plan: $209/mo
• Brand-name semaglutide — Ozempic®, 12-month plan: $1299/mo
• Compounded tirzepatide — Injectable, 12-month plan: $159/mo
• Oral tirzepatide — Oral, 12-month plan: $269/mo

That's under the roughly $165 median I found across the providers I walked — real money back in the grocery budget.

Which meds He and She MD prescribes

He and She MD prescribes semaglutide and tirzepatide — the two with the strongest published weight-loss numbers, and having both on one account genuinely matters if insulin resistance is in the mix (which it often is with PCOS or after gestational diabetes), because that's when tirzepatide tends to be the better fit. It can also route you to FDA-approved brand pens, not just compounded — and the on-label products come with the manufacturer's own pregnancy and lactation labeling, which is a lot cleaner to hand to your OB.

There's a needle-free sublingual option too, which is a relief if injections are the thing stopping you — just set expectations honestly: the under-the-tongue versions are far less studied than the shots the trials actually used.

Who He and She MD is — and isn't — for

A good fit if…

• you want a real person reading your history around nursing and pregnancy timing, not a quiz that rubber-stamps you.
• money is the actual barrier and you want a low, predictable number you can plan around.
• you might need to move between semaglutide and tirzepatide as your body and hormones shift.
• staying covered no matter where you are matters — a move for family shouldn't blow up your care.

Look elsewhere if…

• you'd rather a prescriber actually talk timing around nursing and pregnancy timing — that's what my #1 pick, CoreAge Rx, is built to do.

Can you trust it?

My confidence is middling — the core facts hold up, but some details (per-state availability, how the program really runs) aren't fully public. With any compounded GLP-1, the most useful thing you can do is confirm which licensed pharmacy fills it and what's actually in the formulation — I explain how I weigh oversight in the scoring method.

A standing caveat, because I'm a mom writing this and not your doctor: GLP-1 meds aren't established as safe during pregnancy or breastfeeding, and every label advises against it. Nothing here changes that — plan the timing with your own clinician.

So, would I use it?

He and She MD is a genuine budget play — weigh it on nursing and pregnancy timing and the real monthly cost against the picks below. For most moms, CoreAge Rx is still the stronger all-round fit — and you can see them side by side in this head-to-head.