Open Water Rx review

What I actually think of Open Water Rx

A clean, all-inclusive flat price once you get past the promo codes — $249 semaglutide, $339 tirzepatide, plus a real oral tablet option at $279 — though a genuine price conflict I found across its own pages needed resolving before I'd trust the number. The number they lead with is $159, but the price that sticks is closer to $249/month — so read the headline as a first-month offer, not the real monthly number.

I look at Open Water Rx the way moms actually have to — not just the real monthly number, but nursing and pregnancy timing and the real monthly cost. That's the stuff a generic weight-loss review skips right over.

What Open Water Rx really costs

• Compounded semaglutide — Weekly injection (flat): $159 to start, then $249/mo
• Compounded tirzepatide — Weekly injection (flat): $219 to start, then $339/mo
• Oral semaglutide — Daily tablet: $279/mo

For context, the typical ongoing price across my shortlist is around $168/month, so Open Water Rx sits at the pricey end.

Which meds Open Water Rx prescribes

Open Water Rx prescribes semaglutide and tirzepatide — the two with the strongest published weight-loss numbers, and having both on one account genuinely matters if insulin resistance is in the mix (which it often is with PCOS or after gestational diabetes), because that's when tirzepatide tends to be the better fit. These are compounded from a licensed pharmacy — that's why the price stays down — but compounded GLP-1s aren't FDA-approved finished products the way Wegovy and Zepbound are, and it's worth knowing that going in.

There's a needle-free sublingual option too, which is a relief if injections are the thing stopping you — just set expectations honestly: the under-the-tongue versions are far less studied than the shots the trials actually used.

Who Open Water Rx is — and isn't — for

A good fit if…

• you might need to move between semaglutide and tirzepatide as your body and hormones shift.
• staying covered no matter where you are matters — a move for family shouldn't blow up your care.

Look elsewhere if…

• you specifically want an FDA-approved brand pen with its own pregnancy and lactation labeling.
• you'd rather a prescriber actually talk timing around nursing and pregnancy timing — that's what my #1 pick, CoreAge Rx, is built to do.

Can you trust it?

My confidence is middling — the core facts hold up, but some details (per-state availability, how the program really runs) aren't fully public. With any compounded GLP-1, the most useful thing you can do is confirm which licensed pharmacy fills it and what's actually in the formulation — I explain how I weigh oversight in the scoring method.

One line that's true of every provider on this site: no GLP-1 is established as safe in pregnancy or while breastfeeding, and the labels say don't. This is me reviewing a commercial signup, not giving you a green light — the timing call is yours and your clinician's.

So, would I use it?

Open Water Rx is a reasonable option — weigh it on nursing and pregnancy timing and the real monthly cost against the picks below. For most moms, CoreAge Rx is still the stronger all-round fit — and you can see them side by side in this head-to-head.